Class III biosafety cabinets, which are used extensively throughout Europe, Asia, and Australia but have not yet been adopted in the U.S. Like other isolation cabinets, flexible film cabinets operate under negative air pressure. However, unlike traditional cabinets, flexible film cabinets can easily be demounted and decontaminated giving researchers the flexibility to easily convert a BSL-3 lab into a laboratory that can handle level 4 agents (particularly for diagnostic and small scale work) and back again when necessary.