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Amgen, based in Thousand Oaks, Calif., is considering locations in Research Triangle Park for a new $500-million, 250,000-sf facility. The project would include at least 250,000 sf for biological manufacturing, clinical, and development operations. The biotech company is expanding at its other locations as well. A 92,000-sf research center opened in Cambridge, Mass., late last year; two drug R&D buildings and a parking garage are being added in Thousand Oaks; and the company plans to expand manufacturing at its 232-acre site in Longmont, Colo.