The cancer center will functionally locate both research and clinical programs on the same floor. The research component is designed predominantly in brick, harmonizing and complementing the Thomas Jefferson University campus. The clinical component is designed as a glassy, crystalline element, reinforcing the desire to create an open, non-intimidating environment. The research and clinic components are linked by two-story reception and waiting areas, creating a welcoming environment for patients, clinicians, and researchers to mingle.

The architectural design reflects the dual purpose of the facility and reinforces Thomas Jefferson University's commitment to the urban scale of the neighborhood. The triangular shaped facility allows for the formation of a plaza that is a visual extension of the green space in front of the Bluemle Building. The plaza space is pedestrian oriented. This is reinforced through the ability of the public to circulate along the ground level of the cancer center. An education resource center, retail space, and a 270-seat auditorium are some of the public amenities planned for the ground level.

The laboratory portion of the building will house generic laboratories for biomedical research, clinical research, core facilities, a biological research center, and a vivarium. The building will utilize open, generic, flexible and modular laboratories with research space for 96 Principal Investigators and expansion space for 32 to 36 additional Investigators.

The clinical portion of the facility will also be flexible, housing 36 exam and treatment rooms, 40 infusion spaces, radiation/oncology, MRI, PET scanner, clinical laboratories, and support spaces. In addition, the project will house education and prevention programs, Breast Center, Ambulatory Surgery, a wig bank, an auditorium/conference center, and a new structured parking facility for 290 automobiles.