Renovations to the building began with demolition, leaving a stripped core and shell. The interior upgrades were extensive. Architectural features and building systems were completely renovated or replaced. The renovation included all new partitions, doors, ceilings, windows, HVAC, plumbing, and fire protection. The electrical upgrade included a new UPS system, generator, and transformer. A new hydraulic elevator was installed, and a penthouse was added to house all the mechanical equipment. Seismic upgrades at the window openings were also added to bring the structure up to current codes.

The University directed the design and construction team to make the Rosen Building a laboratory showpiece. All finishes are new including extensive laboratory casework, office casework, flooring, ceilings, bathrooms, millwork, paneling and doors. The laboratories are furnished with maple full overlay casework, white Kemresin countertops, an adjustable island shelving system, and Supreme Air Fume Hoods. The laboratory casework, window trim, doors, and millwork casework are all maple and have matching finishes. The laboratories and their furnishings are the architectural statement of the building interior.