A significant design consideration was the building's flexibility for the future. Lab design is generic to allow these spaces to be tailored to the researcher's specific requirements. The laboratories include wet, dry, laser, high bay, cleanrooms and computer labs with raised floors. Offices are also generic and modular in design, and can be easily converted into laboratory spaces. Proper utility systems were installed in preparation for adaptable uses. A cable tray and backbone conduit system allow for the creation of local area networks throughout the facility.

Another part of the project was the relocation of the power plant for the entire campus to the basement of the new Center. The bulk of the research facility begins at the plaza level rather than the street level, with the 50,000-sf power plant, building common areas and circulation occupying most of the space between these two levels. A rigid reinforced concrete structure was required to resist vibrations from the boiler plant below.

The Schapiro Center expresses connectivity and modern research within the 19th Century stylistic traditions of the campus. High-tech materials -- including metal, window surrounds, ceramic patterned glass and high capacity tube-truss bridges -- set a tone for the 21st Century.