The four-story, 196,578-sf building is composed of four wings arranged around a three-story atrium. This compact plan maximizes the frontage of the interior functions around the skylit atrium, where students and faculty can congregate. Two identical wings contain medical teaching facilities while a curvilinear wing contains stacked lecture halls. The fourth wing houses administrative offices and provides the main entrance to the building. Student-life activities, including an education technology center, student community and organization spaces, are housed on the second floor while the first-floor cafeteria and faculty lounge offer additional areas for social interaction.

The contemporary design reconciles the austere, hard-edged forms of this largely concrete, urban campus with more refined forms and materials. Granite floors, cherry wood and extensive glass are used to create a lively, warm interior setting, in keeping with the School's innovative approach to medical education. On the exterior, two tones of pre-cast cladding are used in combination with metal panels, metal windows and decorative metal fins, to diminish the building's apparent size and to create a dynamic image for this revolutionary educational facility.