The major component of the expansion provides approximately 57,000-sf of additional space for basic and applied research, enabling the hospital to double its number of principal investigators from 15 to 30. Basic research facilities include 24 new biology and biochemistry laboratories. Applied research facilities include office areas for the divisions of Cancer Cause and Prevention and Clinical Investigations. These offices are utilized by the hospital's physicians to apply research to new treatment protocols.

The expansion and renovation project also includes a 45,000-sf medical mall consisting of an enlarged Day Hospital and Outpatient Clinic adjacent to the Patient Health and Education Center and commercial activities, all designed to make outpatient services more immediately available and clearly organized. Additional project components include a conference center, an enlarged clinical laboratory, a materials management facility and a loading dock.