The Drug Discovery area of the building houses three types of lab spaces: screening labs, lead generation labs, and combinatorial chemistry labs. Each laboratory type requires a different level of flexibility. All labs are designed with a large open space in the center with fixed equipment located on the perimeter. The center space is used for setting up mobile and robotic equipment. The utilities are dropped from the ceiling service columns to maintain a high level of flexibility.

The high-throughput screening labs (used to screen the compounds that may lead to medically-useful products) are the most flexible, equipped with movable, adjustable tables in place of island benches allowing re-configuration of the room as often as the screening set-ups change. Workstations are positioned just outside the labs, allowing researchers to view the labs from the office areas. All screening labs, whether designated for medium, high, or ultrahigh throughput testing, are equipped for automated robotic equipment.

Lead generation research spaces have a set-up similar to a fixed casework laboratory. However, moveable tables and ceiling-mounted service columns provide long-term flexibility. Interior perimeter walls function as equipment zones for fixed equipment such as fume hoods, incubators, freezers, coolers, and sinks. The screening and lead generation labs are interchangeable to support varying types of research.

Because they are fume hood intensive, combinatorial chemistry labs are the least flexible of the three spaces. Fume hoods are located in pairs along each interior wall and in groups of four down the middle of the lab modules. Fixed casework with four workstations is set opposite the fume hoods. Each chemist is provided with a galley-style workstation paired with fume hoods and close access to refrigerators and other fixed equipment.

The overall configuration of the building places the combinatorial chemistry labs on the second floor for short, fume hood exhaust runs; screening and lead generation labs on the first floor; and the Information Technology area on the lower floor. Built on a hillside, the facility provides entrances and terraces from the lower and first floors overlooking a small lake.