With three research floors and a prime location within the chemistry complex at Yale University, the 70,000-sf Kline Chemistry building has the highest lab and fume hood density on campus. In renovating the 50-year-old building, the mission was to modernize the lab space while significantly improving building efficiency. In addition to a new building envelope and HVAC systems, conservation strategies include more efficient fume hood use, reduced air changes and power watt densities, minimized outside air and reheat, occupancy controls, and hood proximity sensors. As a result of these efforts, the building is projected to achieve a 30 percent energy cost savings for LEED, and to consume 35 percent less energy than other Yale laboratories. When reductions in fume hood outdoor air demand are included, cost savings are projected to be up to $500,000 beyond those in a typical code-compliant laboratory in this climate zone.