Building density continues to increase and laboratories are expanding vertically with new solutions for development, fit-out, and renovation of highly complex lab space within the upper floors of high-rise buildings. Iain Siery and Matt Decker review solutions for providing flexible and collaborative lab environments in high-rise buildings including navigating code / life safety issues, layout considerations, and blending functional areas. They examine adaptable base-building infrastructure, the integration of tenant specialty systems, and methods to find the appropriate balance of laboratory, laboratory support, office, and mechanical spaces within an established building core and shell.