New answers are required to solve grand challenges, and new facility concepts that eliminate silos and create out-of-the-box thinking are required to prevail. Session leaders illustrate how innovations and shifts in interdisciplinary research environments can be supported through unique governance models, change management tools for transitioning to new workplace models, and plans and designs that embrace non-traditional building users. They detail strategies for academic/corporate partnerships including a “sky lounge” membership approach, and they profile examples of leading corporate, institutional, and academic planning metrics, space layouts, and space assignments. They demonstrate what facility flexibility, adaptability, and scalability mean in this context, innovative approaches to benchmarking and space metrics, financial impacts of space decisions, and aligning space strategies with organizational mission.