Here you’ll see renovation strategies that not only deliver state-of-the-art upgrades to legacy research buildings, but also serve as a catalyst for changing the space use culture. Randy Speight profiles a floor-by-floor renovation initiative to University of Virginia School of Medicine’s Pinn Hall which has transformed previously siloed space into glass-walled labs, offices, and conference rooms that encourage collaboration and allow for efficiencies with technology, equipment, and expertise. He sets out solutions to implementation hurdles including swing space, occupant mindset, and the incorporation of Good Manufacturing Practice (GMP) capabilities, and he previews what may be in store for Phase 2.