The easy answer to increased demand for science and innovation space is to build a new facility, but underappreciated and underutilized older buildings are too often overlooked as a potential resource. Presenters examine build new vs. renovate decision-making rationales being employed to meet increased research space requirements, and they identify cost mitigation effects of responsive programming and facility reuse. They enumerate key functional needs for a diverse range of research labs including bioscience, automation, artificial intelligence, robotics and sustainable design that respond to the increasingly team-based, collaborative, and interdisciplinary activities. They highlight metric and benchmarks from recently completed projects.