Integration of the Arts into Science, Technology, Engineering, and Mathematics (STEM) curricula has been accelerating for many years, but what is the best way to approach the STEAM initiative in new building design? In this session, presenters call upon a case study of the Instructional Laboratory and Innovative Learning Building (ILSQ) at Texas A&M how the building was designed so science and architecture students intentionally and productively collide. They illustrate how to anticipate and reconcile conflicting program requirements to create a culture of collaboration and pave the way for additional, future program combinations.