Many institutions are moving away from purpose driven research labs to maximize long-term facility viability through flexible systems and infrastructure. In this session, Leslie Sims and Angel Flores provide strategies to deliver intense, uber flexible lab environments with infrastructure and MEP systems that can be reconfigured for a range of science programs, augment carbon neutrality, and reduce energy use. They examine multiple recent case studies to compare and contrast purpose-built labs with flexible labs in terms of costs, equipment, operating and safety considerations.