The demand for science spaces at research-oriented universities remains high, and post-pandemic campus planning has created new opportunities for repurposing non-science spaces into spaces for research. Session leaders examine the challenges and strategies employed to convert traditional commercial office space into BSL2/CL2 labs for the University of Toronto's Faculty of Medicine. They detail design solutions creating adaptable, flexible labs instead of labs tailored to a single PI/research focus. They demonstrate how interdisciplinary collaboration and iterative design can deliver efficient, agile, and cost-effective labs and support spaces.