Research industry facilities are now being developed with activity-based workplace designs supporting new collaborative lab-office environments, distinctive amenities, shared resources, and an abundance of natural light. AstraZeneca’s just-opened South San Francisco Site is a leading example of this type of next-generation research workplace. Martin Sharpless and Paul Long illustrate the design rationales, space allocation metrics, designs for collaboration, and the amenities that attract talent and promote innovation. They address efficient space allocation, equipment and lab support shared-access strategies. They also deliver valuable lessons learned from construction through initial occupancy and operations.