This session examines the latest technology innovations and facility design implications for ensuring high-quality, low-variability research while balancing cost, sustainability, and adaptability. Session leaders examine the plethora of factors to be considered, including HVAC systems, humidity across seasons, temperature control for sensitive studies or post-recovery, lighting conditions, variability in room layouts, and more. They illustrate the use of new equipment solutions to allow precise control of extrinsic variables at the cage level, the transformative potential in vivarium design, and the improvements in standardization and reproducibility across studies.