The 17,000-cage vivarium being built for Brown University’s Danoff Life Sciences Laboratories represents a substantial change in operational thinking, and this session traces the evolution of the project from existing conditions to concept and planning, through construction and looking to the future. Presenters chart the transition from a census-based master plan to a flexible design supporting increased density and the incorporation of automation to reduce operating costs. They examine new criteria to drive design evolution without compromising core objectives of efficiency and flexibility. They illustrate the leveraging of a “Choosing by Advantage” strategy to ensure the best value for the University.