Drawing from examples in both Europe and the US, this presentation delivers lessons learned from both sides of the Atlantic, exploring attitudes and trends that define highly successful research endeavors, and what US institutions can learn from the European approach to research development. Presenters examine financing strategies and procurement, flexibility, collaboration culture, energy efficiency, site selection and technical performance in the definition of successful research endeavors, and what drives innovation. They profile evolutionary models for research building and campuses, and innovation in the spatial structures of modern working environments.