Animal Research

The Pirbright Institute has awarded John Sisk & Son a $28.6 million contract to build a research facility for the study of livestock diseases. The two-story, 43,000-sf project is referred to as the CL2 Laboratory and will accommodate 90 scientists. BREAAM Excellent sustainable design certification will be sought for the biocontainment level two facility. The lab is part of a planned $168 million expansion of the Pirbright campus that will include a $118 million facility supporting avian disease research.

The University of Colorado is planning to renovate an existing facility in Boulder to accommodate life sciences research. Providing vivarium and laboratory space, the 60,000-sf facility will enable several animal research programs to be consolidated in a single location. The cost of the purchasing the property is $7.5 million and the University will invest $10.4 million to renovate the building. Construction is expected to begin in spring of 2015 with occupancy in the fall.

Texas A&M University broke ground on a $120 million expansion and renovation of the Veterinary & Biomedical Sciences Education Complex in late April of 2014 in College Station. Designed by SHW Group, the project includes construction of a 330,000-sf facility providing flexible classrooms and laboratories for teaching and research. The existing Small Animal Hospital will also be renovated and expanded. The $93 million construction contract has been awarded to Skanska USA Building and completion is expected in April of 2016.

The University of Washington is planning to build the Animal Research and Care Facility in Seattle. The two-story, subterranean building will provide flexible housing for rodents, pigs, dogs, and non-human primates. Providing approximately 83,000 gsf below grade and 3,000 gsf above grade, the facility will include laboratories, procedure rooms, imaging suites, cage and equipment wash, storage, and other support spaces. The $123.5 million project will consolidate the University’s existing animal research operations into one centralized facility.

MPI Research opened the 10,000-sf Translational Imaging Center in May of 2014 in Mattawan, Mich. Created in partnership with 3D Imaging and inviCRO, the two-story facility will support advanced drug discovery research by providing molecular imaging, autoradiography, and animal modeling in a single location. The project is designed to expedite the translation of preclinical data into clinical data to mitigate risk in the pharmaceutical development process and includes a cyclotron and a vivarium.

Cubresa introduced a compact, affordable SPECT scanner for preclinical research in early 2014. The scanner attaches to existing small animal CT systems, transforming them into multi-modality molecular imaging systems for disease study, translational research, and drug discovery applications. The product features a slim bore which positions the imaging detectors close to the animal subject, optimizing spatial resolution. Advanced detector technology improves sensitivity to balance radiation dose with accelerated study throughput.

Charles River Laboratories opened a 58,000-sf animal research facility in April of 2014 in Spencerville, Ohio. The building provides vivarium space and labs for preclinical research on pharmaceutical compounds, medical devices, and chemicals. Construction on the facility began in 2007 and was halted in 2009, with recommencement of building work in October of 2013.

Aging, inadequate buildings can be redeveloped to create modern animal facilities as long as the design and construction team is armed with the right tools: an accurate assessment of the existing structure and systems, a clear understanding of the challenges they face and the programmatic and budgetary needs of the owners, and a process that allows for constant re-evaluation throughout design and construction.

The Jackson Laboratory (JAX) and the University of California, Davis have initiated a new phase in their ongoing research collaboration by sharing resources and core services. UC Davis will benefit from on-site educational programs at the JAX mouse facility in Sacramento, Calif. JAX will provide mouse colony management services for UC Davis investigators, expediting research discoveries by preventing transportation delays.

TNO Triskelion opened a BSL-3 vaccine testing laboratory in March of 2014 in Zeist. The facility will enable the contract research organization to develop drugs to combat viruses including avian influenza, SARS, and tuberculosis. The biocontainment lab conforms to GLP (Good Laboratory Practice) standards and is able to test treatments against all subtypes of influenza, whether avian or human.

The Public Health Agency of Canada opened the 60,000-sf JC Wilt Infectious Diseases Centre in February of 2014 in Winnipeg. Designed by Smith Carter, the facility provides advanced laboratories for infectious diseases research, diagnostic testing, and early stage vaccine development. Housing up to 200 employees, the Centre includes a training area for biocontainment laboratory operations. The facility will also support research on HIV/AIDS and antimicrobial resistant organisms.

The University of Michigan is planning to build the $261 million Biological Science Building in Ann Arbor. Designed by SmithGroup JJR, the 300,000-sf facility will provide research labs, classrooms, offices, and a vivarium for the Department of Ecology and Evolutionary Biology and the Department of Molecular, Cellular, and Developmental Biology. Providing open, flexible laboratories for collaborative research, the building will be constructed adjacent to the existing Life Sciences Institute to which it will physically connect.

Harlan Laboratories will create an animal research breeding facility in Hyderabad, India. The project will support production of immunodeficient mice for oncology and immunology research. The biosecure facility will supply mice solely to the Indian research market.

The following is a compilation of responses to a survey that asked individuals responsible for planning, design, operations, and maintenance of high-containment facilities to rank their priorities for 2014 and make open-ended comments regarding those priorities. The issues identified in this survey will be the focus of Tradeline’s upcoming conference—The 2014 International Conference on Biocontainment Facilities—on April 10‐11 in Scottsdale, Arizona.

The respondents ranked their overall priorities as follows:

A comprehensive renovation of Harvard University’s 105,000-sf Sherman Fairchild Building for the Stem Cell and Regenerative Medicine Department has allowed researchers to work more efficiently and collaboratively than ever before, with shared fume hoods and environmental, imaging, and equipment rooms. High-use support spaces, such as tissue culture rooms, were moved to the building exterior to take advantage of natural light, while the other shared spaces were moved to the interior.