Animal Research

Misericordia University broke ground in April of 2019 on a $45 million expansion of the Henry Science Center in Dallas Township, Pa. The three-story, 57,400-sf addition will provide classrooms, an electronics fabrication lab, a cadaver suite for the study of anatomy and physiology, and ten teaching labs for biology, chemistry, and physics. The project will also include a cold room for molecular physics experiments, an organic chemistry lab with a 300 megahertz NMR instrument, and vivarium space for small mammals, invertebrates, and aquatics.

The University of Michigan opened the $261 million Biological Science Building in April of 2019 in Ann Arbor. Designed by SmithGroup and Ennead Architects to accommodate 90 principal investigators and their teams, the interdisciplinary building offers 84 wet and dry research labs arranged in open neighborhoods for optimal flexibility.

Operations at the Specific-Pathogen-Free (SPF) vivarium in Australia’s Translational Research Institute (TRI) are likely indicators of trends in animal facilities across the globe. The benefits of automated systems for watering and cagewash, and a robust database to capture a host of operational details—from sterilization runs to task scheduling to costing—have been clearly proven. At the same time, new directions in research, such as study of the microbiome and the gut-brain axis, are sparking a greater need for germ-free and gnotobiotic facilities, a shift that leads to higher ratios of procedure-to-support space and increased staffing levels. The rederivation process and advances in animal health monitoring are also harbingers of change.

A focused and comprehensive programming process was the cornerstone of planning for a new 380,000-sf, seven-story research building at the Centre for Addiction & Mental Health (CAMH) in Toronto, Canada. The building is part of CAMH’s multi-year, multi-phase redevelopment project, which includes construction of new inpatient and outpatient facilities, an emergency department, administrative facilities, and a new research building.

Stanford University opened the $107 million Anne T. and Robert M. Bass Biology Research Building in March of 2019 in Palo Alto, Calif. Designed by Flad Architects and Ennead Architects to promote collaboration and interaction, the 133,000-sf facility provides wet biochemistry labs, dry computational labs, hybrid wet/dry research areas, and classrooms and offices for the Department of Biology.

The University of Texas at El Paso is constructing the $85 million Interdisciplinary Research Building. Designed by Perkins+Will, the 150,000-gsf project will provide collaborative research labs, a vivarium, imaging suites, core labs, a visualization suite, conference rooms, an atrium, an auditorium, and academic and administrative offices. Housing teams from multiple colleges, the flexible facility will be able to adapt with ease to accommodate changing research programs.

Nagasaki University began construction in January of 2019 on a BSL-4 laboratory for the study of infectious diseases and pathogens in Japan. The $68 million biocontainment facility will support basic research to enable the development of innovative diagnosis, treatment, and prevention methods. The project is the first of its kind in the nation, although an existing BSL-4 lab at the National Institute of Infectious Diseases in Musashimurayama provides inspection and testing services. Research operations will begin at the Nagasaki facility in 2022.

In December 2016, Stony Brook Medical launched a plan to build housing for a pair of high-power MRIs, an older model 9.4-Tesla and a newer 7-Tesla. The original plan was to build a brick-and-mortar facility into their existing vivarium, but that was deemed too expensive, forcing them to consider other options. Glen Itzkowitz, dean of facilities and operations, and his team decided to pursue an option that had never been considered at Stony Brook—using pre-fabricated containers to house the MRIs, which they could just barely squeeze into a loading dock underneath a high-traffic footpath, space that was largely being wasted.

The International Microbiome Centre (IMC) at the University of Calgary houses one of the largest germ-free facilities in the world and the only one that has incorporated intra-vital imaging. Constructed in a portion of the basement at the Cumming School of Medicine, the germ-free facility complements the other microbiome platforms—including mass cytometry, genomics, proteomics, metabolomics, bioinformatics, biobanking, and live cell imaging—by providing a model system in which to study the microbiome. The center provides a sterilized housing environment, where researchers explore the microbiome and its impact through adding bacteria to germ-free models and analyzing what those bacteria do to the animals’ immune systems, organs, and overall health.

Masonic Medical Research Institute is constructing a large-animal research facility in its existing building in Utica, N.Y. The $15 million project includes the renovation of a 5,500-sf basement to provide lab space for five investigators and a procedural suite for studies on pigs, sheep, goats, and rabbits. The investment will also support the recruitment of up to 30 new employees.

The Pirbright Institute will begin construction in early 2019 on the £50 million Brooksby Building in the United Kingdom. Designed to promote interaction and collaboration between investigators, the 51,000-sf facility will feature sophisticated biocontainment laboratories for the detection, diagnosis, and study of zoonotic diseases and livestock pathogens, as well as providing small animal vivarium space for in vivo research programs. The general contractor for the project is Kier and occupancy is expected by 2021.

The Vaccines Manufacturing Innovation Centre is planning to create a £66 million research and production facility in the United Kingdom. Located in the Oxford Science Park, the project will support the development and manufacturing of vaccines for clinical trials and epidemic threat mitigation, as well as the creation of gene therapy technologies and personalized medicine solutions.

The University of Nebraska-Lincoln is planning to build a $5 million, 12,490-sf gnotobiotic mouse vivarium adjacent to its existing rodent facility on the East Campus. Providing labs, procedure rooms, a conference room, a staff locker room, and animal holding space, the germ-free facility is being created by the Nebraska Food for Health Center to support research on the human microbiome. Construction will begin in 2019 with completion expected in summer of 2020.

West Texas A&M University will begin construction in December of 2018 on two new veterinary facilities in Canyon, Texas. The $22 million Veterinary Education, Research & Outreach Center will house three BSL-2 labs, a multipurpose teaching lab, a large partitionable classroom, offices, a student commons, and a graduate student bullpen. Offering 22,564 net assignable square feet, the building will include shell space for additional teaching, research, and instructional facilities.

The nation’s academic biomedical research facilities are largely unprepared for natural and man-made disasters that could damage buildings, equipment, IT systems, and materials, and ultimately jeopardize research and scientific careers. A recently released study by the National Academies of Sciences, Engineering, and Medicine calls for institutions and scientists to focus on risk assessment and resilience planning to secure their capital and research investments. In order to do that successfully, institutions need to expand their emergency response and recovery plans and think beyond current building codes, which focus on the life safety needs of the occupants but have yet to account for the significant risks posed to their research programs.