Biotechnology

Pfizer is initiating a $500 million expansion of its Sanford campus with the construction of a 100,000-sf gene therapy facility. Supporting the creation of innovative treatments for genetic diseases, the project will feature advance manufacturing technologies for clinical and commercial-scale production of recombinant adeno-associated virus (rAAV) vectors. Accommodating 300 new employees, the facility will complement operations at the existing 628,000-sf Sanford complex and at the company's Chapel Hill and Kit Creek locations.

Amgen broke ground in late July of 2019 on a $200 million biomanufacturing center in West Greenwich, R.I. Featuring a highly flexible, modular design, the next-generation facility will leverage advanced technologies to reduce operational expenses, consume 80 percent less energy and water, and achieve a 75 percent decrease in carbon emissions.

DLJ Real Estate Capital Partners and Leggat McCall Properties are building a Class-A laboratory building in Somerville, Mass. The nine-story, 289,000-sf facility will provide leading-edge research and office space for life sciences and technology companies. The mixed-use development will include dedicated retail space on the ground floor and four levels of underground parking.

HALIX is constructing a 72,000-sf cGMP facility at Leiden Bio Science Park in the Netherlands. Utilizing 1000-liter, single-use bioreactors, the five-story building will accommodate the development and manufacture of biopharmaceutical drug substances for clinical and commercial applications. Housing labs for process development, analytical development, and quality control, the structure will feature cleanrooms with unidirectional process flows with separate areas for protein manufacturing and the production of viral vaccines and viral vectors.

Adaptive Biotechnologies is expanding its presence in Seattle with the lease of a 100,000-sf headquarters building in Seattle. The lab and office facility is located in the Lake Union life science district and is being developed by Alexandria Real Estate Equities. Adaptive will occupy the entire structure, which is sited adjacent to its existing facility. Building amenities will include an open-air plaza, a rooftop desk, a fitness center, locker and shower rooms, and direct access to water sports on Lake Union.

Foundation Medicine will locate its 580,000-sf life science headquarters in a planned 625,000-sf building in Boston's Seaport Square. Designed by Morris Adjmi Architects and Stantec, the leased building will provide leading-edge research, collaboration, and administrative facilities to support the creation of innovative biomedical therapies.

ADC Bio completed construction of a £5 million bioconjugation cleanroom in July of 2019. Located within the company's 70,000-sf facility in Deeside in the United Kingdom, the GMP lab will support the commercial manufacture of innovative antibody-drug conjugates for the treatment of cancer. Designed and constructed by WHP Engineering, the project houses Grade C and D cleanrooms with four-zone HVAC systems for optimal environmental containment.

The term “Fourth Industrial Revolution” (4IR) was coined in 2016 by Klaus Schwab, founder and executive chairman of the World Economic Forum, to describe the exponential transformation society and commerce are experiencing due to converging breakthroughs in numerous fields, such as artificial intelligence, robotics, 3D printing, nanotechnology, biotechnology, materials science, energy storage, the internet of things (IoT), and quantum computing. While this latest advancement is to some degree an extension of the third revolution (aka: The Digital Revolution), 4IR is considered a new era because of the unprecedented speed, scope, and systems impact of the coming changes. It is evolving at an exponential rate rather than a linear one and is expected to disrupt entire systems of production, management, transportation, and governance on a global scale. In response, a new breed of interdisciplinary research facility is emerging, as academic institutions try to anticipate training students for the unforeseen demands of the 4IR.

ElevateBio has selected DPS Group and TRIA to design ElevateBio BaseCamp, a 108,000-sf cGMP development and manufacturing facility in Waltham. Located in a 430,000-sf office and lab building, the facility will offer integrated R&D, process development, and cGMP manufacturing services for novel therapeutic technologies.

Aldevron will begin construction in August of 2019 on a 14-acre biologics campus in Fargo, N.D., where it is currently headquartered. The first phase comprises a two-story, 189,000-sf facility for the manufacture of plasmid DNA, proteins, mRNA, and antibodies. Increasing Aldevron’s GMP and GMP-Source™ production capacity up to tenfold, the structure will connect to the company's existing GMP facility and is expected to be fully operational by early 2021.

The Wistar Institute is partnering with University Place Associates to construct a 240,000-sf life science discovery hub in the University City district of Philadelphia. Designed to accelerate innovation by providing shared resources and critical infrastructure, the collaborative project will provide leasable laboratories and offices for biotech firms, research companies, and academic institutions.

WuXi Biologics began construction in May of 2019 on a $365 million pharmaceutical production facility in Dundalk, Ireland. Sited on 52 acres, the 522,000-sf contract manufacturing center will utilize single-use technologies and processes, enabling cost-effective scale-out and the simultaneous production of multiple batches of varying volumes. Commercial operations are expected to begin in 2022 at the site, which will be the company's first manufacturing plant outside of China.

Iovance Biotherapeutics entered into a lease agreement in May of 2019 to construct a 136,000-sf facility at the Philadelphia Navy Yard. Featuring modular processes for optimal scalability, the building will support commercial and clinical production of therapeutics based on tumor-infiltrating lymphocyte (TIL) technologies. The $125 million facility is slated for completion in mid-2021. Iovance will contribute approximately $75 million towards the cost of the building over three years for equipment and construction of the manufacturing suites.

Chugai Pharmaceuticals will begin construction in August of 2019 on a $1.15 billion research and development center in Yokohama, Japan. Consolidating two labs currently sited in Gotemba and Kamakura, the facility will support drug discovery including the creation of therapies based on next-generation antibodies and synthetic macrocycles, also known as middle molecules. The pharmaceutical research center will leverage leading-edge automation processes and artificial intelligence technologies to accelerate the delivery of innovative medicines to patients worldwide.

WuXi Biologics began construction in May of 2019 on a 1.3 million-sf integrated manufacturing center in Chengdu, China. Meeting the criteria of both the U.S. Food and Drug Administration and the European Medicines Agency's GMP guidelines, the biologics hub will include both drug development and commercial manufacturing facilities. Offering an initial bioreactor capacity of 48,000 liters, the project is WuXi's twelfth drug substance manufacturing plant and will use the company's open-access and proprietary platforms.