Most research universities carry an inventory of aging, mission-critical science and engineering buildings that no longer serve evolving programs and that hide big deferred maintenance liabilities. Drawing on precinct plans and renewal strategies developed for leading institutions, presenters synthesize the patterns that consistently drive successful outcomes. They deliver a streamlined, repeatable framework for assessing building viability—comparing reinvestment versus replacement, creating defensible cases for full rebuild, and aligning scope, cost, and phasing with long-term research goals. They provide a proven toolkit for creating condition assessments, decision matrices, and constrained-environment funding strategies.