Bioprocessing

EMD Serono is planning to construct a $70 million R&D facility on its existing campus in Billerica, Mass. Supporting research programs in oncology, immuno-oncology, and immunology, the 145,000-sf building will accommodate wet labs, offices, collaboration spaces, and a cafeteria. Designed to attain LEED and WELL certification, the project will provide a healthy and sustainable environment for approximately 400 employees. Completion is expected in 2021. EMD Serono is the biopharmaceutical business of Merck KGaA, based in Darmstadt, Germany.

Catalent is initiating an expansion of its biologics manufacturing operations. The global biotechnology company will construct a 60,000-sf facility on its existing campus in Madison, Wis. The project is slated for completion by 2021 and represents an investment of $100 million over the next three years. Catalent will also invest $100 million to increase its manufacturing capacity in Bloomington, Ind.

Brammer Bio is developing two gene therapy manufacturing facilities in Massachusetts. The company will build out 35,000 sf in an existing 50,000-sf structure in Lexington to create a cGMP manufacturing and quality control operations center. Additionally, Brammer will renovate 8,000 sf in its 66,000-sf commercial cGMP plant in Cambridge to create new production suites to support manufacturing capacity expansion. DPS Group is providing architectural and engineering services for both projects, which are slated for completion in mid-2019.

Fujifilm Cellular Dynamics is creating a stem cell manufacturing center in Madison, Wis. Located in the University Research Park, the $21 million project involves the renovation of 31,500 sf in a facility near the company's existing lab and office building. The completed biomanufacturing plant will meet the requirements of the U.S. Food and Drug Administration. Completion is expected by March of 2020.

Mustang Bio completed construction of its 27,000-sf cell therapy manufacturing center in November of 2018. Located in the UMass Medicine Science Park in Worcester, the facility supports the clinical development and commercialization of Mustang's CAR-T and gene therapy product candidates. Accommodating proprietary cell therapy research, the project involved the renovation of labs and offices, as well as the conversion of existing labs to create three cGMP ISO7 clinical production areas.

WuXi Biologics began construction in October of 2018 on its Manufacturing Center of Excellence in Shijiazhuang, China. Providing 48,000 liters of production capacity, the facility will meet international cGMP standards and will utilize disposable bioreactors. WuXi Biologics expects to have over 220,000 liters of manufacturing capacity by 2021.

Ajinomoto Althea is building a 57,000-sf pharmaceutical manufacturing facility in San Diego. Accommodating all stages of development from preclinical production through commercial supply, the project will support the manufacture of highly potent drug products as well as Antibody Drug Conjugates (ADCs). The facility will enable the safe handling and manipulation of compounds with very low occupational exposure limits (OEL) while maintaining aseptic conditions and cGMP compliance.

Atara Biotherapeutics opened a $55 million manufacturing facility in June of 2018 in Thousand Oaks, Calif. Designed by HPA Architects to meet LEED sustainable design criteria, the Atara T-cell Operations and Manufacturing (ATOM) center houses a 90,000-sf facility for the production of CAR-T allogeneic therapies, as well as additional R&D labs and offices. The project was developed by Sares-Regis Group with Atara signing a 15-year lease for the building.

Merck will begin construction in the third quarter of 2018 on a biologics facility in County Dublin, Ireland. Located on Merck's 33-acre campus in Swords, the project includes the renovation and expansion of an existing 341,000-sf structure to create a 470,000-sf facility offering laboratory, production, and warehouse space. The state-of-the-art pharmaceutical plant will manufacture protein therapeutics derived from mammalian cell cultures. Occupancy is expected in 2021.

Thomas Jefferson University is planning to create the Jefferson Institute for Bioprocessing in Lower Gwynedd, Pa. Located at Spring House Innovation Park, the 25,000-sf facility is being developed in partnership with the National Institute for Bioprocessing Research and Training (NIBRT) based in Dublin, Ireland. As the only center of its kind in North America, the project will leverage the renowned NIBRT curriculum to deliver state-of-the-art education and training programs in biopharmaceutical processing to approximately 2,500 people annually.

SAB Biotherapeutics will occupy 41,000 sf in University of South Dakota's Discovery District in Sioux Falls. SAB, a clinical-stage biopharmaceutical company, will locate its corporate headquarters, research labs, and a cGMP suite in the 84,000-sf building, which was designed by Perkins+Will and Architecture Incorporated. Alumend, a subsidiary of Avera, will occupy 7,500 sf in the $31 million facility, which will also house the offices of the USD Discovery District and 20,000 sf of leasable space.

Cambrex Corporation, a leading manufacturer of small molecule innovator and generic Active Pharmaceutical Ingredients (APIs), completed an expansion of its pilot plant in High Point in May of 2018. The project included the installation and commissioning of a fourth reactor suite, increasing the site's capacity by approximately 30 percent. The 400-sf suite houses two 2,000-liter glass-lined reactors and a Hastelloy C22 filter dryer, allowing the manufacture of batch sizes between 10 and 100 kilograms under cGMP conditions.

Global biopharmaceutical company Bristol-Myers Squibb opened a 62,000-sf biologics discovery center on its Redwood City campus in April of 2018. Designed by Stantec to support the development of new cancer therapies, the facility provides research labs and 115 perimeter workstations in an open office environment. The building is illuminated by abundant natural light and offers huddle rooms and conference rooms adjoining the main circulation area to enhance collaboration.

Zoetis broke ground in April of 2018 on a 463,000-sf animal vaccine center in Suzhou, China. Combining research and development operations with integrated manufacturing and supply, the facility will produce vaccines for swine, cattle, fish, and companion animals. Offering sophisticated innovation suites and certified GMP laboratories, the project will support research on disease threats prevalent in China with a primary focus on aquaculture.

Lonza opened a 300,000-sf cell and gene therapy manufacturing center in April of 2018 in Pearland, Texas. The facility features eight independent cGMP modular cleanrooms with single-use bioreactors and a fully segregated fill/finish suite. Supporting the development of new therapies from initial concept through the pre-clinical, clinical, and commercialization phases, the integrated building includes research labs, offices, manufacturing and production spaces, and support.