Biocontainment

The award-winning Eva J. Pell Laboratory provides Biosafety Level Three (BSL-3) and Animal Biosafety Level Three (ABSL-3) high-containment laboratory space for pathogen and toxin research to support a growing infectious disease research program at Pennsylvania State University. The facility has been designed to support advanced research using CDC/USDA Select Agents. As many as 15 researchers—working in BSL-2, BSL-3, and ABSL-3 containment—study human and animal health issues they were previously unable to safely address on campus.

The National Institutes of Health opened a BSL-3 laboratory in Islamabad, Pakistan, in January of 2014. The facility will enable the rapid detection of biological agents and pathogens that pose a threat to public health. The lab will also accommodate research in virology and molecular biology in partnership with academic and industry partners.

Bringing biosafety laboratories into compliance with the BMBL 5^th Edition’s “zero airflow reversal” clause requires assessing risk appropriately, analyzing the impact of a pressure envelope on the facility, installing appropriate ventilation and control systems, and implementing new control strategies for practical testing.

Emory University’s 200,000-sf Health Sciences Research Building (HSRB) provides both wet and dry labs and BSL-2 and BSL-3 containment to pursue research in drug discovery, immunology and vaccines, neurosciences, cancer, gastroenterology, transplant immunology, nephrology, biomedical engineering, and human genetics.

Harlan Laboratories will create an animal research breeding facility in Hyderabad, India. The project will support production of immunodeficient mice for oncology and immunology research. The biosecure facility will supply mice solely to the Indian research market.

The following is a compilation of responses to a survey that asked individuals responsible for planning, design, operations, and maintenance of high-containment facilities to rank their priorities for 2014 and make open-ended comments regarding those priorities. The issues identified in this survey will be the focus of Tradeline’s upcoming conference—The 2014 International Conference on Biocontainment Facilities—on April 10‐11 in Scottsdale, Arizona.

The respondents ranked their overall priorities as follows:

Successful biosafety management combines progressive training programs with an operations and maintenance structure that creates a culture of cooperation, resulting in less downtime during required or emergency maintenance. This, in turn, increases researchers’ productivity and saves millions of dollars in grant money that can otherwise be lost during maintenance breaks.

The District of Columbia received approval in November of 2013 from the Centers for Disease Control and Prevention to begin BSL-3 research operations at the Consolidated Forensics Laboratory in Washington. The secure facility will enable the city's Public Health Laboratory to perform biological analysis of select agents and toxins. The $210 million, 300,000-sf Consolidated Forensics Laboratory opened in fall of 2012.

The new Consolidated Forensic Laboratory (CFL) in the heart of Washington, D.C., not only merges the physical environs of three city public safety agencies—public health, the chief medical examiner, and the forensics labs—but also creates a new dynamic for interagency cooperation. Co-location in the 351,000-sf, six-story, state-of-the-art facility allows the city to upgrade all three agencies cost effectively while improving the science, efficiency, and integrity of the work performed there. The efficiency extends to the building systems, with the CFL achieving LEED Platinum.

The Coachella Valley Mosquito and Vector Control District is constructing a new BSL-3 laboratory, to be completed in March 2014, to reduce turnaround time on mosquito testing by bringing currently outsourced procedures in-house. The District is dedicated to arbovirus (arthropod-borne virus) surveillance, focusing on mosquito abundance, mosquito infections, and avian infections to target mosquito control in areas that are the most important to preventing disease transmission. By limiting mosquito control to selected areas, the District lowers expense, time, and labor, and minimizes harm to the environment.

The Australian Animal Health Laboratory (AAHL), a high-containment facility in Geelong, Victoria, has been operating 24/7 with no shutdowns, even for maintenance or upgrades, for nearly 30 years, thanks to the initial design, selection of materials, and quality of construction.

The AAHL—with BSL-2, BSL-3, and BSL-4 biocontainment areas—has an extensive redundant plant to ensure that critical systems, such as the air handling units, remain continually operational. The facility was one of the first in the world to use microprocessor control for all engineering systems.

A study at Yale University suggests that quantitative performance analysis of laboratory airflow may show more conclusive results than traditional methods of measurement, and thus obviate the perceived need for costly retrofits and upgrades in order to comply with the CDC/NIH’s new prohibition against reversal of airflow under failure conditions found in Biosafety in Microbiological and Biomedical Laboratories 5^th Edition (BMBL).

AgriBio, Centre for AgriBioscience is one of Australia's premier biosciences facilities, with a key emphasis on supporting and protecting Victoria's $8.4 billion (USD) agricultural sector by focusing on cutting-edge research to improve productivity, fight disease, and reduce environmental impact. The state-of-the-art research facility serves joint venture partners La Trobe University (La Trobe) and the Victorian Department of Primary Industries (DPI).

The University of Edinburgh opened the first phase of the National Avian Research Facility in early 2013. The $7.9 million facility is part of a collaborative two-building research campus currently under construction for the Roslin Institute of the Royal (Dick) School of Veterinary Studies and The Pirbright Institute. Ground was broken on the project in early 2013. Phase two of the $22 million project is expected to open in late 2014.

Non-residential construction volumes and pricing continued their upward trend in the second quarter, with prices increasing an average of 2 to 4 percent in the first half of 2013. These factors, along with growing market confidence and a narrowing labor supply, will continue to push new construction costs closer to the trend line for the near to medium term.