Biocontainment

An “onion skin” layout of lab adjacencies and biocontainment strategies derived from a thorough risk assessment process are highlights of the new construction for the South Dakota Animal Disease Research and Diagnostic Laboratory (ADRDL) in Brookings, S.D. The new 84,000-gsf (41,000-nsf) building, an addition to the original facility, will provide space to accommodate the burgeoning demand for molecular diagnostics while bringing activities on both sides of the ADRDL mission—research and diagnostics—under one roof.

HALIX opened a 72,000-sf biopharmaceutical development and manufacturing center in November of 2019 at Leiden Bio Science Park in the Netherlands. The five-story structure provides BSL-2 cleanrooms with unidirectional process flows that can easily be upgraded to BSL-3 as needed. A manufacturing line with a 250-liter bioreactor capacity supports the production of viral vaccines and viral vectors, while a separate protein manufacturing area accommodates single-use bioreactors with a capacity of up to 1,000 liters.

The Ohio State University is planning to construct two collocated research facilities in its West Campus innovation district in Columbus. Designed by Pelli Clarke & Partners and Moody Nolan, the 305,000-sf Interdisciplinary Research Facility will provide a vivarium, support spaces, and wet, computational, and core labs for programs in engineering and medical research.

Stanford University opened a $256 million biomedical research complex in November of 2019 in Stanford, Calif. Designed by Ennead Architects, the four-story, 235,000-sf project includes the Stanford ChEM-H (Chemistry, Engineering & Medicine for Human Health) Building and the Stanford Neurosciences Building, which houses the Wu Tsai Neurosciences Institute.

Texas Tech University opened the $77 million Experimental Sciences Building II in October of 2019 in Lubbock, Texas. Comprising four stories and a basement level, the 117,000-gsf facility provides collaborative environments for interdisciplinary research including four general wet labs, three core instrumentation suites, two synthetic labs, a vivarium, a BSL-2 lab, conference rooms, and offices for researchers and principal investigators.

North Carolina State University broke ground on the $160 million Plant Sciences Building in Raleigh in September of 2019. Designed by Flad Architects, the five-story, 184,000-sf facility will allow academic, government, and industry researchers to develop innovative solutions for global agricultural challenges. Located on the Centennial Campus, the building will house growth chambers, environmental rooms, core instrumentation suites, and labs for genotyping, spectrometry, ag-bio engineering, and chemical and soils analysis.

Pennsylvania State University is planning to construct the $98.5 million Animal, Veterinary and Biomedical Sciences Building in University Park. Designed by HOK, the 105,000-sf facility will provide the College of Agricultural Sciences with research labs, a general-purpose classroom, faculty offices, seminar rooms, and a state-of-the-art vivarium.

The South Dakota Animal Disease Research and Diagnostic Laboratory (ADRDL) celebrated the opening of its expanded Brookings facility in September of 2019. The $58 million project included construction of an 81,000-sf addition offering 3,762 sf of biocontainment space which provides BSL-2E necropsy and BSL-3 facilities. A 4,000-sf chiller plant was also constructed. General contractor McCownGordon broke ground on the expansion in August of 2017. The lab's existing 55,000-sf facility will now undergo renovation and completion is expected in May of 2020.

HALIX is constructing a 72,000-sf cGMP facility at Leiden Bio Science Park in the Netherlands. Utilizing 1000-liter, single-use bioreactors, the five-story building will accommodate the development and manufacture of biopharmaceutical drug substances for clinical and commercial applications. Housing labs for process development, analytical development, and quality control, the structure will feature cleanrooms with unidirectional process flows with separate areas for protein manufacturing and the production of viral vaccines and viral vectors.

ADC Bio completed construction of a £5 million bioconjugation cleanroom in July of 2019. Located within the company's 70,000-sf facility in Deeside in the United Kingdom, the GMP lab will support the commercial manufacture of innovative antibody-drug conjugates for the treatment of cancer. Designed and constructed by WHP Engineering, the project houses Grade C and D cleanrooms with four-zone HVAC systems for optimal environmental containment.

Premier BioSource opened a 78,000-sf swine production facility in July of 2019 in Rensselaer, Ind. Designed as a barrier facility with advanced HEPA filtration and positive air pressure systems, the $7.5 million farrow-to-finish complex will enable biomedical research on the creation of organs for xenotransplantation in humans. Supporting lean manufacturing operations, the biocontainment facility features advanced building systems including individual controls for the air pressure in each room and an energy recovery wheel for optimal heat exchange.

Colorado State University broke ground in July of 2019 on the $22 million Center for Vector-Borne Infectious Diseases in Fort Collins. Designed by Merrick & Company and BSA LifeStructures, the 41,000-sf research facility will house the Department of Microbiology, Immunology and Pathology. The project will provide offices, support space, and BSL-2 labs for the detection and study of arthropod-borne and infectious diseases.

Texas A&M University opened the $104 million Medical Research and Education Building II (MREB II) in June of 2019 in Bryan, Texas. Designed by Flad Architects and OMNIPLAN, the 155,077-sf project comprises a 48,200-sf vertical expansion to the existing Medical Research and Education Building (MREB I) and a 122,800-sf addition, enabling the College of Medicine's basic science departments to be collocated in a single campus.

Hackensack Meridian Health opened the Center for Discovery and Innovation in May of 2019 in Nutley, N.J. Located on the ON3 campus adjacent to Hackensack Meridian School of Medicine at Seton Hall University, the 250,000-sf translational research facility will accelerate the creation of innovative therapeutics for the treatment of cancer, diabetes, dementia, antibiotic-resistant infections, and autoimmune disorders. The center houses the Institute for Regenerative Medicine, the Institute for Multiple Myeloma, and the Institute for Cancer and Infectious Disease.

Nagasaki University began construction in January of 2019 on a BSL-4 laboratory for the study of infectious diseases and pathogens in Japan. The $68 million biocontainment facility will support basic research to enable the development of innovative diagnosis, treatment, and prevention methods. The project is the first of its kind in the nation, although an existing BSL-4 lab at the National Institute of Infectious Diseases in Musashimurayama provides inspection and testing services. Research operations will begin at the Nagasaki facility in 2022.