Biocontainment

Amgen broke ground in March of 2022 on a $550 million biomanufacturing center in Holly Springs, N.C. Accommodating the company's FleXBatch platform, the project will integrate traditional methods for drug substance production with single-use bioprocessing technologies to create a hybrid facility with unrivaled operational efficiencies. The next-generation plant will manufacture advanced therapeutics for the treatment of cardiovascular disease, cancer, osteoporosis, inflammation, and other conditions.

The University of Wyoming opened the $100 million Science Initiative Building in March of 2022 in Laramie. Designed by GSG Architecture and Perkins&Will, the 153,000-sf structure will enhance interaction among multiple disciplines by collocating researchers into a single complex with shared core facilities. Located on the first floor to mitigate vibration, the Center for Advanced Scientific Instrumentation provides electron microscopes, an X-ray refractometer, a mass spectrometer, and micro CT scanners.

Vibalogics completed construction in December of 2021 on a $150 million virotherapy facility in Boxborough, Mass. Sited on 145 acres, the next-generation manufacturing plant supports commercial production of oncolytic viruses, viral vector vaccines, and viral vector gene therapy products. The highly flexible structure incorporates 2,000-liter bioreactors, multiple cGMP production suites, offices, warehouse space, and labs for research, development, and quality control.

Pfizer opened a $68.5 million clinical manufacturing facility in December of 2021 in Durham. Accommodating the company's BioTherapeutics Pharmaceutical Sciences division, the 85,500-sf project will support the creation of gene therapies for the treatment of hemophilia A, hemophilia B, Duchenne muscular dystrophy, and other diseases. Leveraging single-use bioreactors to enable scalable expansion over time, the structure provides multiple drug substance suites, analytical and microbiology labs, and areas for manufacturing and filling. 

Washington University School of Medicine will break ground in spring of 2022 on a $150 million vertical expansion of the Steven & Susan Lipstein BJC Institute of Health in St. Louis. Designed by Lawrence Group to promote collaboration and discovery, the six-story, 160,000-sf addition will provide 103,000 sf of biomedical research space and a 7,900-sf BSL-3 laboratory for the study of infectious diseases such as SARS-CoV-2 and tuberculosis.

Texas Biomedical Research Institute broke ground in December of 2021 on a $15 million nonhuman primate complex in San Antonio. Part of the Southwest National Primate Research Center, the four-building expansion will feature three large structures offering indoor and outdoor housing environments. An 18,000-sf animal care facility will provide a state-of-the-art veterinary clinic, pathology labs, and a staff meeting hub.

Pennsylvania State University opened the $98.5 million Animal, Veterinary and Biomedical Sciences Building in December of 2021 in University Park. Designed by HOK, the 105,000-sf facility provides the College of Agricultural Sciences with a state-of-the-art vivarium, a general-purpose classroom capable of accommodating 100 students, a 48-seat seminar room, and faculty offices.

BeiGene is planning to break ground in 2022 on a pharmaceutical manufacturing and research center in Hopewell, N.J. Located on the Princeton West Innovation Campus, the integrated complex will provide 400,000 sf of dedicated space for commercial-stage production of innovative cancer therapies. Offering up to 16,000 liters of biologics capacity, the facility will also include clinical R&D labs and collaborative office environments. IPS is the architect and engineer for the project, which will be built by DPR Construction.

Rocky Mountain Laboratories began construction in December of 2021 on a $93 million animal research vivarium in Hamilton, Mont. Accelerating the detection and mitigation of emerging infectious diseases, the 120,000-sf structure will provide climate-controlled environments for rodents, ticks, bats, and other species. The technology-rich building will also house an analytical lab and collaborative workspaces for researchers and staff.

Moderna is partnering with Alexandria Real Estate Equities to create a 462,000-rsf headquarters and research facility at the Alexandria Center development at One Kendall Square. Accelerating the discovery and development of mRNA vaccines and therapeutics, the collaborative structure will feature leading-edge R&D labs, sophisticated offices, and engaging gathering spaces.

Tonix Pharmaceuticals broke ground in August of 2021 on the 45,000-sf Advanced Development Center in Dartmouth, Mass. Enabling the production of clinical-stage vaccines for COVID-19 and other infectious diseases, the BSL-2 facility will utilize single-use bioreactors and purification suites for optimal efficiency and flexibility. The cGMP center will also offer state-of-the-art research, development, and analytical suites. Approximately 70 scientists, technicians, and manufacturing staff will work in the turnkey building. 

Ivanhoé Cambridge and Lendlease will break ground in summer of 2022 on a 320,000-sf life sciences facility in Boston. Designed by SGA, the nine-story building will provide state-of-the-art labs, offices, and collaboration spaces for biomedical and pharmaceutical tenants. Offering BSL-1 and BSL-2 research environments, the amenity-rich structure will include a multipurpose ground floor, a parking garage, and numerous outdoor areas.

Precision NanoSystems is constructing its global headquarters in Vancouver, British Columbia. Located in the four-story Evolution Block building, the 75,000-sf leased facility will feature a GMP biomanufacturing center for the production of genetic medicines and RNA-based therapeutics. The federal government has contributed CAD$25.1 million in funding towards the project's construction to increase the nation's domestic supply of COVID-19 vaccines and prepare for future pandemics.

Washington State University dedicated the $61.9 million Washington Animal Disease Diagnostic Laboratory in May of 2021. Designed by Perkins&Will, the 61,000-sf facility represents an expansion of the Paul G. Allen Center for Global Animal Health in Pullman. Enabling the detection and diagnosis of human and animal diseases including SARS-CoV-2, avian influenza, BSE, and West Nile virus, the three-story building houses instructional venues, collaboration spaces, a high-bay necropsy suite, and specialized labs for testing, research, and development.

The International Society for Pharmaceutical Engineering has announced the 2021 Facility of the Year Awards category winners. The awards include: