Biotechnology

Merck is constructing a $69 million facility for the production of high-potency active pharmaceutical ingredient (HPAPI) and antibody-drug conjugate (ADC) compounds. Representing an expansion of the company's existing campus near Madison, the 70,000-sf structure will feature containment environments specifically designed for the manufacture of substances with single-digit nanogram occupational exposure limits. The building will allow the large-scale production of increasingly potent compounds for the creation of innovative cancer therapeutics.

Facility Logix, EwingCole, and Biggins Lacy Shapiro have launched Rapid Reshore & Development (RR&D) to provide turnkey professional services to the life sciences and biopharmaceutical industries. Addressing many of the logistical challenges faced by companies developing drugs, vaccines, and medical devices, the alliance represents an evolution from transaction-driven service models to a holistic focus on client needs.

Construction began in October of 2020 on the $44.2 million Discovery Square 2 building in Rochester, Minn. Designed by RSP Architects, the 125,000-sf facility will offer leasable research environments for life science companies. Sited in the Destination Medical Center district, the five-story structure will feature advanced laboratory infrastructure, centralized common spaces, and a physical connection to the adjacent One Discovery Square building.

King Street Properties has fully leased a 214,440-sf research facility in Lexington, Mass., to four pharmaceutical companies. Designed by R E Dinneen Architects & Planners, the four-story building will offer leading-edge lab and office environments for biomedical research. JLL is the leasing agent for the development, which has yet to open. Tenants include:

Fujifilm Diosynth Biotechnologies broke ground in August of 2020 on the $55 million Advanced Therapies Innovation Center in College Station, Texas. Representing an expansion of Fujifilm's cGMP manufacturing campus, the 60,000-sf facility will feature dedicated labs for process development and innovation. Research environments with BSL-2 capabilities will integrate advanced technologies for upstream, downstream, and analytical development.

Codiak BioSciences is constructing a 12,000-sf clinical manufacturing center in Lexington, Mass. The project includes the build-out of a leased lab and office building to create a GMP facility for the production of exosome therapeutics. Codiak is incorporating G-CON Manufacturing's PODs into the center to provide flexible cleanroom capacity. The prefabricated units offer exceptional scalability and mobility, and can be easily repurposed to meet future needs.

CRISPR Therapeutics signed a full-building lease in July of 2020 for a 263,500-sf facility in Boston's Seaport district. Breakthrough Properties is the developer for the project, which was designed by Payette to provide best-in-class laboratory environments for life science research. Both LEED Gold and Fitwel certification will be sought for the structure, which will offer multiple amenities including outdoor terraces and a fitness center.

Lincoln Property Company broke ground in July of 2020 on a 140,000-sf life science building in Waltham, Mass. Designed by DiMella Shaffer in collaboration with AHA Consulting Engineers, the four-story structure will offer 35,000 sf of flexible and customizable office and laboratory space on each floor. A robust mechanical penthouse will support the installation of sophisticated infrastructure, and highly resilient energy and telecommunications services will be ensured by an onsite emergency power supply.

The Cell and Gene Therapy Catapult is planning to create the Manufacturing Innovation Centre in Braintree in the United Kingdom. Supported by £100 million in government funding, the project will enable mass production of a COVID-19 vaccine. An existing pharmaceutical plant has been purchased from Benchmark Holdings at a cost of £16 million. The structure's GMP infrastructure for antigen production, formulation, process development, and scale manufacturing will be repurposed and enhanced. Completion is expected in December of 2021.

DiNAQOR AG completed construction in July of 2020 on a 9,687-sf R&D center in Schlieren, Switzerland. Located in the Bio-Technopark Schlieren-Zürich, the BSL-2 facility will enable DiNAQOR to fast-track the development of its human-induced pluripotent stem cells (iPSC) and engineered heart tissue platform. Accelerating the creation of next-generation genetic medicine methodologies, the project also provides sophisticated infrastructure to further optimize the company's proprietary locoregional heart perfusion approach.

Winstanley Enterprises is planning to build a $100 million bioscience research building in New Haven, Conn. Designed by Elkus Manfredi Architects, the 10-story, 500,000-sf facility will provide leasable laboratory and office environments for life science companies and academic institutions. Featuring a large public plaza, the project will include a conference center, a 50,000-sf business incubator, and a classroom for K-12 educational programs.

MilliporeSigma, a subsidiary of Merck, is planning to expand its existing campus in Buchs, Switzerland, with the construction of a $20 million laboratory for the company's reference materials business. Accommodating 40 employees, the three-story, 12,000-sf structure will provide analytical and R&D suites for the testing of pharmaceuticals, environmental materials, and food and beverage products.

SiO2 Materials Science is investing $163 million to expand its production capacity for vaccine vials and syringes in Auburn, Ala. The company will increase the footprint of its existing facility in the Auburn Technology Park West to create a 70,000-sf manufacturing center with additional space for precision injection molding operations. A second molding plant will also be constructed nearby. 

Wake Technical Community College is constructing the $33.4 million Lilly Science and Technology Center in Morrisville, N.C. Designed by O'Brien Atkins Associates, the 66,000-sf facility will provide sophisticated classrooms and laboratories for the school's growing biotechnology programs. The three-story structure will accommodate a biopharmaceutical simulation suite, a cleanroom for training courses in aseptic processing techniques, information technology labs, and conference rooms.

Trammell Crow Company will break ground in July of 2020 on Fulton Labs in Chicago. Providing wet and dry research environments, the 16-story, 423,454-sf life science facility will offer column-free and long-span layouts as well as a dedicated innovation floor for early-stage companies. Designed for maximum flexibility and scalability, the 16-story structure will integrate advanced mechanical infrastructure to support advanced R&D enterprises, with all labs meeting VC-A vibration criteria to ensure reproducible research results.