City of Hope Opens Specialty Cancer Hospital in Orange County

City of Hope celebrated the opening of a $452 million specialty cancer facility in December of 2025 in Irvine, Calif. Designed by HOK, the 73-bed hospital accommodates intensive care and medical-surgical units, four operating rooms, two procedure rooms, and an eight-bed evaluation and treatment center. The six-story structure also accommodates an inpatient rehabilitation gym, an immersive multifaith spiritual zone, and outdoor terraces on each floor. 

Sited on City of Hope’s 72-acre academic research campus, the 164,000-sf building offers seamless connections to the Lennar Foundation Cancer Center to create a next-generation model of advanced care. An integrated surgical system between these facilities enables real-time expert consultation to enhance the delivery of precise and innovative treatments. The healthcare nexus also provides patients with access to novel, cancer-specific clinical trials, including complex and early-stage interventions focused on hematology and solid tumors.

Hensel Phelps was the design-build contractor for the transformative project, with Jacobs as project manager and Freeman Group as owner’s representative.