Compliance

State-of-the-art labs are more efficient, cheaper, and more pleasant for the animals housed there than older designs. Despite all these advantages, most labs are decades out of date, say laboratory architect Jeff Zynda of Perkins&Will and laboratory veterinary consultant John J. Hasenau. The longtime collaborators point out that outdated labs are missing out on a broad range of improvements—from more efficient HVAC systems to a deeper understanding of light spectrums to better cage design—that are more comfortable for the animals, more useful for the scientists, and less expensive to operate.

Designing and building labs in the unlikely and constrained location of the prestigious Pacific Design Center (PDC) with Hollywood as a backdrop is a daunting task, requiring adherence to quality expectations, facilities management guidelines in a non-research environment, separation from existing high-end tenants, and compliance with infrastructure requirements. Cedars-Sinai, one of the largest nonprofit medical centers in the U.S., accepted the challenge after deciding to expand its research portfolio. Growing beyond its limited campus is necessary to accommodate the rapid growth of its research facilities and to aid in recruiting top scientists by providing innovative facilities with optimum resources. Hospital officials looked a half mile from their campus to the PDC, a designated cultural resource building complex designed by Cesar Pelli in the 1970s. Known in the 1980s and 1990s as a vibrant hub of premier art, design, and architectural showrooms, many of the tenants now have online shops rather than physical space in the cluster of buildings, leaving vacancies available for lease and an opportunity for Cedars-Sinai’s growth.

Three years after the end of the pandemic, office occupancies have still not gone back to where they were pre-COVID, and there is a wide range of opinions about whether they should. While some executives have ordered everyone back into the office, arguing that being physically present facilitates engagement and innovation, many workers argue that their working life and their home life are better when they can choose where they log on.

Designing higher education labs is sometimes as much about managing the chemicals that inhabit the space as it is about the scientists and their work in the lab. How hazardous are the chemicals? How are they stored, and what are the allowable quantities? How do you protect the researchers and occupants in adjacent spaces, both during normal lab operations and in an emergency? Is it possible to craft a code-compliant chemical management strategy that aligns with the current shift toward large open labs that foster interdisciplinary collaboration? 

How do you know if an existing building has what it takes to house a new specialty laboratory? The planning effort has to go beyond the typical process for a conventional lab renovation of defining program needs and investigating existing conditions. It must instead drill down into the unique aspects of the specialized environment, including illuminating the key attributes of the already-occupied and operational facility. 

The number of makerspaces has increased 200% nationally in the last decade, with no sign of slowing down. This bodes well for the future of the labor force. But given the type of technology and materials used in these spaces, they also present a multitude of code, infrastructure, and safety challenges. Assess the risks posed by the various makerspace activities, and learn the regulations that apply to everything from welding and wood processing to painting and 3D printing. 

The use of animals in biomedical research, already a decades-long ethically charged issue, has come under fire in more recent years for both a lack of scientific rigor and its huge financial appetite. Concerns about waste in basic research—in animal lives, scientist time, and research costs—are mounting, particularly when investigators are unable to confirm the data and achieve the same results when replicating original experiments (either theirs or others’). The solution? Track the effects of extrinsic environmental factors that can impact an animal's behavior, health, and reproduction: temperature, humidity, light, noise, and vibration.

Increasing demand for BSL-3 and ABSL-3 lab space in the wake of the COVID-19 pandemic is driving up interest in renovating existing research facilities to accommodate these high-containment spaces. Even a small BSL-3 lab can be a costly undertaking, with special attention required for security of both personnel and biohazards, location in the building, and waste disposal, as well as the design and commissioning of exhaust system.

Philadelphia-based Genesis AEC was able to reduce the square footage of a new translational medicine center of excellence by more than half and cut cost estimates by 16%, by reviewing the client’s needs versus wants; using innovative design practices, including a first-of-its-kind firewall design; and applying the approach known as “engineering, procurement, and construction management (EPCM).” The facility for a U.S.-based multi-national pharmaceutical company opened on Sept. 1, 2023.

Virginia Tech is planning to construct a $292 million engineering building in the North Academic District in Blacksburg. Replacing an existing structure, Mitchell Hall will act as a centralized hub for several departments including mechanical, chemical, computer, and aerospace and ocean engineering. The five-story, 285,500-gsf development was designed by Perkins&Will to foster experiential learning with student collaboration spaces on every level.

Repurposing non-research facilities to house specialized life sciences and therapeutics labs is a growing trend sparked by real estate inventory and the fiscal practicality of renovation rather than new construction. The vacancy rate throughout the United States for lab space in the fourth quarter of 2022 was 6 percent versus 19.5 percent for office space, according to the Jones Lang LaSalle real estate transparency index. The vacancy rates for 2021 were less than 4 percent for labs and approximately 15 percent for offices.

Life science laboratories are increasingly embracing the idea of moving into high-rise settings in city centers, filling space in new construction, or renovating office space left vacant, in part, by the many companies opting to continue to work from home following the pandemic. High-rise laboratories in urban settings offer many advantages related to recruiting top talent, the ease of city amenities, and abundant transportation options, says Matthew Decker, AIA, architect for CRB in Plymouth Meeting, Penn. But they also pose challenges, including strict building codes for hazardous materials, and infrastructure concerns that can affect placement of lab equipment, HVAC systems, and utilities.

The Sixth Edition of the Biosafety in Microbiological and Biomedical Laboratories (BMBL) manual emphasizes the importance of risk assessment and management, communication among all stakeholders, comprehensive procedures to report accidents and exposures, and a new focus on biocontainment of pathogens affecting agricultural animals. First published in 1984, the BMBL still serves as the cornerstone of biosafety practices for the safe conduct of research throughout the world.

The Olivia Business Centre was awarded the highest WELL Health-Safety Rating in March of 2021 by the International WELL Building Institute. Located in Gdańsk, Poland, the eight-building corporate park offers 2.5 million sf of world-class office space and accommodates over 200 companies. Achieving 25 out of 25 available points in all WELL Health-Safety categories, the complex leverages advanced infrastructure to continue operations safely during the COVID-19 pandemic. Features include:

Alexandria Real Estate Equities has attained the world's first WELL Health-Safety Rating for laboratory space at Alexandria LaunchLabs in New York City. Augmenting the center’s existing WELL certification for building design, the WELL Health-Safety Rating for Facilities Operations and Management includes further measures to protect the health of tenants, employees, visitors, and service personnel. Protocols at Alexandria LaunchLabs include: